Melissa and I watched The Station Agent a few weeks ago on the recommendation of a coworker of hers. I had never heard of it before, but it really is a fantasic movie. I think it has some of most unique characters I've seen in a while, and it has tons of rolling-on-the-floor-hilarious lines as well as dealing with some tough emotional issues.
Rotten Tomatoes rates it at 95% right now. If you haven't seen it and you're looking for something a little different, I'd very much recommend it.